This combined package of Regional Updates showcases the breadth and depth of the Good Health and Wellness in Indian Country (GHWIC) initiative through a regional lens. Within this package are two-page summary documents crafted by Tribal Epidemiology Centers (TECs). Each Regional Update corresponds with an Indian Health Service (IHS) Area and profiles the work of Tribes, Tribal-serving health organizations, and TECs as they promote chronic disease prevention among American Indian and Alaska Native (AI/AN) people through policy, systems, and environmental changes. These documents showcase a diversity of work conducted by GHWIC grantees to improve the health of AI/ANs through sustainable interventions and community change. TECs engage and guide GHWIC grantees within their regions on evaluation activities that reflect local community assets and complement cultural strengths.